Predicting hospitalization and mortality in patients with heart failure: the BARDICHE-index
Background - Prediction of events in chronic heart failure (CHF) patients is still difficult and available scores are often complex to calculate. Therefore, we developed and validated a simple-to-use, multidimensional prognostic index for such patients. - Methods - A theoretical model was developed...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
International journal of cardiology
Year: 2016, Volume: 227, Pages: 901-907 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2016.11.122 |
| Online Access: | Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1016/j.ijcard.2016.11.122 Verlag, Pay-per-use, Volltext: http://www.sciencedirect.com/science/article/pii/S0167527316335811 
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| Author Notes: | Nicole H.M.K. Uszko-Lencer, Lutz Frankenstein, Martijn A. Spruit, Micha T. Maeder, Marc Gutmann, Stefano Muzzarelli, Stefan Osswald, Matthias E. Pfisterer, Christian Zugck, Hans-Peter Brunner-La Rocca, the TIME-CHF Investigators |
| Summary: | Background - Prediction of events in chronic heart failure (CHF) patients is still difficult and available scores are often complex to calculate. Therefore, we developed and validated a simple-to-use, multidimensional prognostic index for such patients. - Methods - A theoretical model was developed based on known prognostic factors of CHF that are easily obtainable: Body mass index (B), Age (A), Resting systolic blood pressure (R), Dyspnea (D), N-termInal pro brain natriuretic peptide (NT-proBNP) (I), Cockroft-Gault equation to estimate glomerular filtration rate (C), resting Heart rate (H), and Exercise performance using the 6-min walk test (E) (the BARDICHE-index). Scores were given for all components and added, the sum ranging from 1 (lowest value) to 25 points (maximal value), with estimated risk being highest in patients with highest scores. Scores were categorized into three groups: a low (≤8 points); medium (9-16 points), or high (>16 points) BARDICHE-score. The model was validated in a data set of 1811 patients from two prospective CHF-cohorts (median follow-up 887days). The primary outcome was 5-year all-cause survival. Secondary outcomes were 5-year survival without all-cause hospitalization and 5-year survival without CHF-related hospitalization. - Results - There were significant differences between BARDICHE-risk groups for mortality (hazard ratio=3.63 per BARDICHE-group, 95%-CI 3.10-4.25), mortality or all-cause hospitalization (HR=2.00 per BARDICHE-group, 95%-CI 1.83-2.19), and mortality or CHF-related hospitalization (HR=3.43 per BARDICHE-group, 95%-CI 3.01-3.92; all P<10-50). Outcome was predicted independently of left ventricular ejection fraction (LVEF) and gender. - Conclusions - The BARDICHE-index is a simple multidimensional prognostic tool for patients with CHF, independently of LVEF. |
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| Item Description: | Gesehen am 17.10.2018 Article was first available online on 9 November 2016 |
| Physical Description: | Online Resource |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2016.11.122 |