BID links ferroptosis to mitochondrial cell death pathways
Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by erastin-med...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2017
|
| In: |
Redox Biology
Year: 2017, Volume: 12, Pages: 558-570 |
| ISSN: | 2213-2317 |
| DOI: | 10.1016/j.redox.2017.03.007 |
| Online Access: | Resolving-System, Volltext: http://dx.doi.org/10.1016/j.redox.2017.03.007 Verlag, Volltext: https://www.sciencedirect.com/science/article/pii/S2213231717300654 
|
| Author Notes: | Sandra Neitemeier, Anja Jelinek, Vincenzo Laino, Lena Hoffmann, Ina Eisenbach, Roman Eying, Goutham K. Ganjam, Amalia M. Dolga, Sina Oppermann, Carsten Culmsee |
| Summary: | Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by erastin-mediated inhibition of the Xc- system or inhibition of glutathione peroxidase 4 (Gpx4) to an increasing number of oxidative cell death paradigms in cancer cells, neurons or kidney cells, the biochemical pathways of oxidative cell death remained largely unclear. In particular, the role of mitochondrial damage in paradigms of ferroptosis needs further investigation. |
|---|---|
| Item Description: | Available online 9 March 2017 Gesehen am 22.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2213-2317 |
| DOI: | 10.1016/j.redox.2017.03.007 |