Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach
Machine learning systems have recently received increased attention for their broad applications in several fields. In this study, we show for the first time that histological types of breast tumors can be classified using subtle morphological differences of microenvironmental myoepithelial cell nuc...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 April 2017
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| In: |
Scientific reports
Year: 2017, Volume: 7 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep46732 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/srep46732 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/srep46732 
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| Author Notes: | Yoichiro Yamamoto, Akira Saito, Ayako Tateishi, Hisashi Shimojo, Hiroyuki Kanno, Shinichi Tsuchiya, Ken-ichi Ito, Eric Cosatto, Hans Peter Graf, Rodrigo R. Moraleda, Roland Eils & Niels Grabe |
| Summary: | Machine learning systems have recently received increased attention for their broad applications in several fields. In this study, we show for the first time that histological types of breast tumors can be classified using subtle morphological differences of microenvironmental myoepithelial cell nuclei without any direct information about neoplastic tumor cells. We quantitatively measured 11661 nuclei on the four histological types: normal cases, usual ductal hyperplasia and low/high grade ductal carcinoma in situ (DCIS). Using a machine learning system, we succeeded in classifying the four histological types with 90.9% accuracy. Electron microscopy observations suggested that the activity of typical myoepithelial cells in DCIS was lowered. Through these observations as well as meta-analytic database analyses, we developed a paracrine cross-talk-based biological mechanism of DCIS progressing to invasive cancer. Our observations support novel approaches in clinical computational diagnostics as well as in therapy development against progression. |
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| Item Description: | Gesehen am 22.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep46732 |