Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes
Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophil...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2012
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| In: |
The journal of allergy and clinical immunology
Year: 2012, Volume: 130, Issue: 3, Pages: 607-612.e9 |
| ISSN: | 1097-6825 |
| DOI: | 10.1016/j.jaci.2012.02.019 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jaci.2012.02.019 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S009167491200348X 
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| Author Notes: | Peter Valent, Amy D. Klion, Hans-Peter Horny, Florence Roufosse, Jason Gotlib, Peter F. Weller, Andrzej Hellmann, Georgia Metzgeroth, Kristin M. Leiferman, Michel Arock, Joseph H. Butterfield, Wolfgang R. Sperr, Karl Sotlar, Peter Vandenberghe, Torsten Haferlach, Hans-Uwe Simon, Andreas Reiter, and Gerald J. Gleich |
| Summary: | Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophilic disorders and related syndromes have been proposed in various fields of medicine. Although criteria and definitions are, in part, overlapping, no global consensus has been presented to date. The Year 2011 Working Conference on Eosinophil Disorders and Syndromes was organized to update and refine the criteria and definitions for eosinophilic disorders and to merge prior classifications in a contemporary multidisciplinary schema. A panel of experts from the fields of immunology, allergy, hematology, and pathology contributed to this project. The expert group agreed on unifying terminologies and criteria and a classification that delineates various forms of hypereosinophilia, including primary and secondary variants based on specific hematologic and immunologic conditions, and various forms of the hypereosinophilic syndrome. For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. The proposed novel criteria, definitions, and terminologies should assist in daily practice, as well as in the preparation and conduct of clinical trials. |
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| Item Description: | Available online 27 March 2012 Gesehen am 24.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1097-6825 |
| DOI: | 10.1016/j.jaci.2012.02.019 |