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Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis

Background: The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages. Here we investigate whether the degree of systemic inflammation (QuinA, neopte...

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Main Authors: Lahdou, Imad (Author) , Sadeghi, Mahmoud (Author) , Oweira, Hani (Author) , Fusch, Gerhard (Author) , Daniel, Volker (Author) , Mehrabi, Arianeb (Author) , Jung, Gregor Eric (Author) , Elhadedy, Hazem (Author) , Schmidt, Jan (Author) , Şandra-Petrescu, Flavius Ionuţ (Author) , Iancu, Mircea (Author) , Opelz, Gerhard (Author) , Terness, Peter (Author) , Schefold, Joerg C. (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Human immunology
Year: 2013, Volume: 74, Issue: 1, Pages: 60-66
ISSN:1879-1166
DOI:10.1016/j.humimm.2012.09.009
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.humimm.2012.09.009
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0198885912005605
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Author Notes:Imad Lahdou, Mahmoud Sadeghi, Hani Oweira, Gerhard Fusch, Volker Daniel, Arianeb Mehrabi, GE. Jung, Hazem Elhadedy, Jan Schmidt, Flavius Sandra-Petrescu, Mircea Iancu, Gerhard Opelz, Peter Terness, Joerg C. Schefold
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Summary:Background: The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages. Here we investigate whether the degree of systemic inflammation (QuinA, neopterin, CRP and IL-6) correlates with clinical liver dysfunction according to the MELD Score. Method: Ninety-four patients with liver cirrhosis were categorized into 2 groups according to baseline MELD score (group I, MELD <20, n=61, and group II, MELD ⩾20, n=33). Results: Serum levels of QuinA, neopterin, CRP, and IL-6 significantly correlated with MELD score (r=0.77, 0.75, 0.57, and 0.50; p<0.0001, respectively). Patients of group II had significantly higher serum levels of QuinA, neopterin, CRP, and IL-6 than group I (p⩽0.0001). ROC curve analysis showed that QuinA and neopterin are more sensitive markers for severity of liver disease than established markers of inflammation such as CRP and IL-6 (sensitivity=86% and 79%, respectively) (AUC=0.89 and 0.89, respectively). QuinA provided the most sensitive index with regard to the identification of patients with hepatic encephalopathy. Conclusion: Serum levels of QuinA reflect the degree of liver dysfunction. Moreover, high levels of QuinA may serve as a sensitive indicator of hepatic encephalopathy.
Item Description:Available online 6 October 2012
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Physical Description:Online Resource
ISSN:1879-1166
DOI:10.1016/j.humimm.2012.09.009

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