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Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis

Background: The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages. Here we investigate whether the degree of systemic inflammation (QuinA, neopte...

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Hauptverfasser: Lahdou, Imad (VerfasserIn) , Sadeghi, Mahmoud (VerfasserIn) , Oweira, Hani (VerfasserIn) , Fusch, Gerhard (VerfasserIn) , Daniel, Volker (VerfasserIn) , Mehrabi, Arianeb (VerfasserIn) , Jung, Gregor Eric (VerfasserIn) , Elhadedy, Hazem (VerfasserIn) , Schmidt, Jan (VerfasserIn) , Şandra-Petrescu, Flavius Ionuţ (VerfasserIn) , Iancu, Mircea (VerfasserIn) , Opelz, Gerhard (VerfasserIn) , Terness, Peter (VerfasserIn) , Schefold, Joerg C. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2013
In: Human immunology
Year: 2013, Jahrgang: 74, Heft: 1, Pages: 60-66
ISSN:1879-1166
DOI:10.1016/j.humimm.2012.09.009
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.humimm.2012.09.009
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0198885912005605
Volltext
Verfasserangaben:Imad Lahdou, Mahmoud Sadeghi, Hani Oweira, Gerhard Fusch, Volker Daniel, Arianeb Mehrabi, GE. Jung, Hazem Elhadedy, Jan Schmidt, Flavius Sandra-Petrescu, Mircea Iancu, Gerhard Opelz, Peter Terness, Joerg C. Schefold
Beschreibung
Zusammenfassung:Background: The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages. Here we investigate whether the degree of systemic inflammation (QuinA, neopterin, CRP and IL-6) correlates with clinical liver dysfunction according to the MELD Score. Method: Ninety-four patients with liver cirrhosis were categorized into 2 groups according to baseline MELD score (group I, MELD <20, n=61, and group II, MELD ⩾20, n=33). Results: Serum levels of QuinA, neopterin, CRP, and IL-6 significantly correlated with MELD score (r=0.77, 0.75, 0.57, and 0.50; p<0.0001, respectively). Patients of group II had significantly higher serum levels of QuinA, neopterin, CRP, and IL-6 than group I (p⩽0.0001). ROC curve analysis showed that QuinA and neopterin are more sensitive markers for severity of liver disease than established markers of inflammation such as CRP and IL-6 (sensitivity=86% and 79%, respectively) (AUC=0.89 and 0.89, respectively). QuinA provided the most sensitive index with regard to the identification of patients with hepatic encephalopathy. Conclusion: Serum levels of QuinA reflect the degree of liver dysfunction. Moreover, high levels of QuinA may serve as a sensitive indicator of hepatic encephalopathy.
Beschreibung:Available online 6 October 2012
Gesehen am 21.09.2021
Beschreibung:Online Resource
ISSN:1879-1166
DOI:10.1016/j.humimm.2012.09.009

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