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Inhibition of osteoclast generation: a novel function of the bone morphogenetic protein 7/Osteogenic Protein 1

Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts. The microenvironment, particularly cytokines, directs the monocyte differentiation. Receptors of NFB (RANK) ligand, tumor necrosis factor (TNF) , or interleukin- (IL-) 8 have be identified as ind...

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Bibliographic Details
Main Authors: Maurer, Thomas B. (Author) , Zimmermann, Gerald (Author) , Maurer, Susanne (Author) , Stegmaier, Sabine (Author) , Wagner, Christof (Author) , Hänsch, Gertrud Maria (Author)
Format: Article (Journal)
Language:English
Published: 27 September 2012
In: Mediators of inflammation

ISSN:1466-1861
DOI:10.1155/2012/171209
Online Access:Verlag, Volltext: http://dx.doi.org/10.1155/2012/171209
Verlag, Volltext: https://www.hindawi.com/journals/mi/2012/171209/
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Author Notes:Thomas Maurer, Gerald Zimmermann, Susanne Maurer, Sabine Stegmaier, Christof Wagner, and G. Maria Hänsch
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Summary:Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts. The microenvironment, particularly cytokines, directs the monocyte differentiation. Receptors of NFB (RANK) ligand, tumor necrosis factor (TNF) , or interleukin- (IL-) 8 have be identified as inducers of osteoclastogenesis, whereas others, such as IL-10 or transforming growth factor (TGF) inhibit osteoclast generation or induce differentiation towards a dendritic cell type. We now describe that bone morphogenetic protein (BMP) 7/osteogenic protein- (OP-) 1 inhibited the differentiation of human CD14
Item Description:Gesehen am 26.10.2018
Physical Description:Online Resource
ISSN:1466-1861
DOI:10.1155/2012/171209

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