Inhibition of osteoclast generation: a novel function of the bone morphogenetic protein 7/Osteogenic Protein 1
Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts. The microenvironment, particularly cytokines, directs the monocyte differentiation. Receptors of NFB (RANK) ligand, tumor necrosis factor (TNF) , or interleukin- (IL-) 8 have be identified as ind...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 September 2012
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| In: |
Mediators of inflammation
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| ISSN: | 1466-1861 |
| DOI: | 10.1155/2012/171209 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1155/2012/171209 Verlag, Volltext: https://www.hindawi.com/journals/mi/2012/171209/ 
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| Verfasserangaben: | Thomas Maurer, Gerald Zimmermann, Susanne Maurer, Sabine Stegmaier, Christof Wagner, and G. Maria Hänsch |
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| 520 | |a Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts. The microenvironment, particularly cytokines, directs the monocyte differentiation. Receptors of NFB (RANK) ligand, tumor necrosis factor (TNF) , or interleukin- (IL-) 8 have be identified as inducers of osteoclastogenesis, whereas others, such as IL-10 or transforming growth factor (TGF) inhibit osteoclast generation or induce differentiation towards a dendritic cell type. We now describe that bone morphogenetic protein (BMP) 7/osteogenic protein- (OP-) 1 inhibited the differentiation of human CD14 | ||
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