Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned 23 Na/ 1 H resonator systems
A double-tuned 23 Na/ 1 H resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. 1 H-diffusion-, 1 H perfusion, 1 H T 2 -, 1 H arterial blood flow- and 23 Na spin density-weighted images were then acquired at three time points in a rodent st...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
9 October 2012
|
| In: |
Physics in medicine and biology
Year: 2012, Volume: 57, Issue: 21, Pages: 6929 |
| ISSN: | 1361-6560 |
| DOI: | 10.1088/0031-9155/57/21/6929 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1088/0031-9155/57/21/6929 Verlag, Volltext: http://stacks.iop.org/0031-9155/57/i=21/a=6929 
|
| Author Notes: | Friedrich Wetterling, Saema Ansar and Eva Handwerker |
| Summary: | A double-tuned 23 Na/ 1 H resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. 1 H-diffusion-, 1 H perfusion, 1 H T 2 -, 1 H arterial blood flow- and 23 Na spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal 23 Na was detected in hypoperfused stroke tissue which exhibited a low 1 H apparent diffusion coefficient (ADC) and no changes in 1 H T 2 relaxation time during transient ischemia, while 23 Na increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned 1 H/ 23 Na birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear 23 Na/ 1 H MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high 23 Na at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear 23 Na/ 1 H MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue. |
|---|---|
| Item Description: | Gesehen am 29.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1361-6560 |
| DOI: | 10.1088/0031-9155/57/21/6929 |