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Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction

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KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose t...

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Bibliographic Details
Main Authors: Zavaritskaya, Olga (Author) , Gloe, Torsten (Author) , Devermann, Lena (Author) , Schubert, Rudolf (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Hypertension
Year: 2012, Volume: 61, Issue: 1, Pages: 151-159
ISSN:1524-4563
DOI:10.1161/HYPERTENSIONAHA.112.197566
Online Access:Verlag, Volltext: http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.197566
Verlag, Volltext: https://www.ahajournals.org/cgi/doi/10.1161/HYPERTENSIONAHA.112.197566
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Author Notes:Olga Zavaritskaya, Nadezda Zhuravleva, Johanna Schleifenbaum, Torsten Gloe, Lena Devermann, Reinhart Kluge, Mitko Mladenov, Manfred Frey, Hristo Gagov, Gabor Fésüs, Maik Gollasch, Rudolf Schubert
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Summary:KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue and that they represent novel targets to rescue periadventitial vascular dysfunction. Two models, spontaneously hypertensive rats and New Zealand obese mice, were studied using quantitative polymerase chain reaction, the patch-clamp technique, membrane potential measurements, myography of isolated vessels, and blood pressure telemetry. In rat Gracilis muscle arteries, anticontractile effects of perivascular fat were inhibited by the KCNQ channel blockers XE991 and linopirdine but not by other selective K+ channel inhibitors. Accordingly, XE991 and linopirdine blocked noninactivating K+ currents in freshly isolated Gracilis artery smooth muscle cells. mRNAs of several KCNQ channel subtypes were detected in...
Item Description:Originally published 26 Nov 2012
Gesehen am 30.10.2018
Physical Description:Online Resource
ISSN:1524-4563
DOI:10.1161/HYPERTENSIONAHA.112.197566

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