Intra-individual comparison of 68Ga-PSMA-11-PET/CT and multi-parametric MR for imaging of primary prostate cancer
Purpose: Multi-parametric magnetic resonance imaging (MP-MRI) is currently the most comprehensive work up for non-invasive primary tumor staging of prostate cancer (PCa). Prostate-specific membrane antigen (PSMA)-Positron emission tomography-computed tomography (PET/CT) is presented to be a highly p...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2016
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| In: |
European journal of nuclear medicine and molecular imaging
Year: 2016, Volume: 43, Issue: 8, Pages: 1400-1406 |
| ISSN: | 1619-7089 |
| DOI: | 10.1007/s00259-016-3346-0 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00259-016-3346-0 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906063/ 
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| Author Notes: | F.L. Giesel, F. Sterzing, H.P. Schlemmer, T. Holland-Letz, W. Mier, M. Rius, A. Afshar-Oromieh, K. Kopka, J. Debus, U. Haberkorn, C. Kratochwil |
| Summary: | Purpose: Multi-parametric magnetic resonance imaging (MP-MRI) is currently the most comprehensive work up for non-invasive primary tumor staging of prostate cancer (PCa). Prostate-specific membrane antigen (PSMA)-Positron emission tomography-computed tomography (PET/CT) is presented to be a highly promising new technique for N- and M-staging in recurrent PCa-patients. The actual investigation analyses the potential of 68Ga-PSMA11-PET/CT to assess the extent of primary prostate cancer by intra-individual comparison to MP-MRI. Methods: In a retrospective study, ten patients with primary PCa underwent MP-MRI and PSMA-PET/CT for initial staging. All tumors were proven histopathological by biopsy. Image analysis was done in a quantitative (SUVmax) and qualitative (blinded read) fashion based on PI-RADS. The PI-RADS schema was then translated into a 3D-matrix and the euclidian distance of this coordinate system was used to quantify the extend of agreement. Results: Both MP-MRI and PSMA-PET/CT presented a good allocation of the PCa, which was also in concordance to the tumor location validated in eight-segment resolution by biopsy. An Isocontour of 50 % SUVmax in PSMA-PET resulted in visually concordant tumor extension in comparison to MP-MRI (T2w and DWI). For 89.4 % of sections containing a tumor according to MP-MRI, the tumor was also identified in total or near-total agreement (euclidian distance ≤1) by PSMA-PET. Vice versa for 96.8 % of the sections identified as tumor bearing by PSMA-PET the tumor was also found in total or near-total agreement by MP-MRI. Conclusions: PSMA-PET/CT and MP-MRI correlated well with regard to tumor allocation in patients with a high pre-test probability for large tumors. Further research will be needed to evaluate its value in challenging situation such as prostatitis or after repeated negative biopsies. |
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| Item Description: | Im Titel ist die Zahl 68 als Hochzahl dargestellt Gesehen am 02.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1619-7089 |
| DOI: | 10.1007/s00259-016-3346-0 |