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Intra-individual comparison of 68Ga-PSMA-11-PET/CT and multi-parametric MR for imaging of primary prostate cancer

Purpose: Multi-parametric magnetic resonance imaging (MP-MRI) is currently the most comprehensive work up for non-invasive primary tumor staging of prostate cancer (PCa). Prostate-specific membrane antigen (PSMA)-Positron emission tomography-computed tomography (PET/CT) is presented to be a highly p...

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Hauptverfasser: Giesel, Frederik L. (VerfasserIn) , Sterzing, Florian (VerfasserIn) , Schlemmer, Heinz-Peter (VerfasserIn) , Holland-Letz, Tim (VerfasserIn) , Mier, Walter (VerfasserIn) , Afshar-Oromieh, Ali (VerfasserIn) , Kopka, Klaus (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Haberkorn, Uwe (VerfasserIn) , Kratochwil, Clemens (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: July 2016
In: European journal of nuclear medicine and molecular imaging
Year: 2016, Jahrgang: 43, Heft: 8, Pages: 1400-1406
ISSN:1619-7089
DOI:10.1007/s00259-016-3346-0
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1007/s00259-016-3346-0
Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906063/
Volltext
Verfasserangaben:F.L. Giesel, F. Sterzing, H.P. Schlemmer, T. Holland-Letz, W. Mier, M. Rius, A. Afshar-Oromieh, K. Kopka, J. Debus, U. Haberkorn, C. Kratochwil
Beschreibung
Zusammenfassung:Purpose: Multi-parametric magnetic resonance imaging (MP-MRI) is currently the most comprehensive work up for non-invasive primary tumor staging of prostate cancer (PCa). Prostate-specific membrane antigen (PSMA)-Positron emission tomography-computed tomography (PET/CT) is presented to be a highly promising new technique for N- and M-staging in recurrent PCa-patients. The actual investigation analyses the potential of 68Ga-PSMA11-PET/CT to assess the extent of primary prostate cancer by intra-individual comparison to MP-MRI. Methods: In a retrospective study, ten patients with primary PCa underwent MP-MRI and PSMA-PET/CT for initial staging. All tumors were proven histopathological by biopsy. Image analysis was done in a quantitative (SUVmax) and qualitative (blinded read) fashion based on PI-RADS. The PI-RADS schema was then translated into a 3D-matrix and the euclidian distance of this coordinate system was used to quantify the extend of agreement. Results: Both MP-MRI and PSMA-PET/CT presented a good allocation of the PCa, which was also in concordance to the tumor location validated in eight-segment resolution by biopsy. An Isocontour of 50 % SUVmax in PSMA-PET resulted in visually concordant tumor extension in comparison to MP-MRI (T2w and DWI). For 89.4 % of sections containing a tumor according to MP-MRI, the tumor was also identified in total or near-total agreement (euclidian distance ≤1) by PSMA-PET. Vice versa for 96.8 % of the sections identified as tumor bearing by PSMA-PET the tumor was also found in total or near-total agreement by MP-MRI. Conclusions: PSMA-PET/CT and MP-MRI correlated well with regard to tumor allocation in patients with a high pre-test probability for large tumors. Further research will be needed to evaluate its value in challenging situation such as prostatitis or after repeated negative biopsies.
Beschreibung:Im Titel ist die Zahl 68 als Hochzahl dargestellt
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Beschreibung:Online Resource
ISSN:1619-7089
DOI:10.1007/s00259-016-3346-0

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