Sample sizes for time-to-event endpoints: should you insure against chance variations in accrual?
This note addresses the questions of whether one should safeguard against a potential loss of power due to random variations of the accrual time, how this “insurance” can be formulated, and how much the sample size needs to be increased to obtain it.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2012
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| In: |
Contemporary clinical trials
Year: 2012, Volume: 33, Issue: 2, Pages: 456-458 |
| ISSN: | 1559-2030 |
| DOI: | 10.1016/j.cct.2011.10.009 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.cct.2011.10.009 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1551714411002667 
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| Author Notes: | Ulrich R. Abel, Katrin Jensen, Irini Karapanagiotou-Schenkel |
| Summary: | This note addresses the questions of whether one should safeguard against a potential loss of power due to random variations of the accrual time, how this “insurance” can be formulated, and how much the sample size needs to be increased to obtain it. |
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| Item Description: | Available online 9 November 2011 Gesehen am 30.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1559-2030 |
| DOI: | 10.1016/j.cct.2011.10.009 |