M3: an integrative framework for structure determination of molecular machines
We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 August 2017
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| In: |
Nature methods
Year: 2017, Volume: 14, Issue: 9, Pages: 897-902 |
| ISSN: | 1548-7105 |
| DOI: | 10.1038/nmeth.4392 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/nmeth.4392 Verlag, Volltext: https://www.nature.com/articles/nmeth.4392 
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| Author Notes: | Ezgi Karaca, João P.G.L.M. Rodrigues, Andrea Graziadei, Alexandre M.J.J. Bonvin, Teresa Carlomagno |
| Summary: | We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic levels and accepts input from all structural and biochemical experiments whose data can be translated into interatomic distances and/or molecular shapes. |
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| Item Description: | Gesehen am 09.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1548-7105 |
| DOI: | 10.1038/nmeth.4392 |