Cover Image

Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant

Objectives: The etiology and genetic susceptibility of primary central nervous system vasculitis (PCNSV) are still unclear.Patients and methods: We analyzed the DNA of 25 Caucasian patients with PCNSV for human leucocyte antigen genes HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1, respectively. HLA-frequenci...

Full description

Saved in:
Bibliographic Details
Main Authors: Krämer, Markus (Author) , Berlit, Peter (Author)
Format: Article (Journal)
Language:English
Published: September 2017
In: Clinical neurology and neurosurgery
Year: 2017, Volume: 160, Pages: 137-141
ISSN:1872-6968
DOI:10.1016/j.clineuro.2017.06.009
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.clineuro.2017.06.009
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0303846717301762
Get full text
Author Notes:Markus Kraemer, Jana Becker, Peter A. Horn, Jan Claudius Schwitalla, Kathy Keyvani, Imke Metz, Christiane Wegner, Wolfgang Brück, Marc Schlamann, Falko M. Heinemann, Peter Berlit
Description
Summary:Objectives: The etiology and genetic susceptibility of primary central nervous system vasculitis (PCNSV) are still unclear.Patients and methods: We analyzed the DNA of 25 Caucasian patients with PCNSV for human leucocyte antigen genes HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1, respectively. HLA-frequencies of the 25 patients with PCNSV were compared with HLA-frequencies of matched Caucasian controls. Results: No statistically significant associations were found for HLA-B, HLA-DR1 and HLA-DQB1 variant. In the PCNSV group, only the HLA-A*69 variant was found more often than expected statistically. Conclusion: The results of this study indicate a potential association of HLA marker with PCNSV in Caucasian patients. Further studies are needed to elucidate the role of genes within the human major histocompatibility complex in the pathogenesis of this angiopathy.
Item Description:Available online 23 June 2017
DOI funktioniert nicht
Gesehen am 12.11.2018
Physical Description:Online Resource
ISSN:1872-6968
DOI:10.1016/j.clineuro.2017.06.009

Similar Items