Cover Image

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

Objective Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method This prospective meta-analysis i...

Full description

Saved in:
Bibliographic Details
Main Authors: Walton, Esther (Author) , Gruber, Oliver (Author) , Richter, Anja (Author) , Krämer, Bernd (Author)
Format: Article (Journal)
Language:English
Published: 29 March 2017
In: Acta psychiatrica Scandinavica
Year: 2017, Volume: 135, Issue: 5, Pages: 439-447
ISSN:1600-0447
DOI:10.1111/acps.12718
Online Access:Verlag, Volltext: http://dx.doi.org/10.1111/acps.12718
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12718
Get full text
Author Notes:E. Walton, D.P. Hibar, T.G.M. van Erp, S.G. Potkin, R. Roiz‐Santiañez, B. Crespo‐Facorro, P. Suarez‐Pinilla, N.E.M. Van Haren, S.M.C. de Zwarte, R.S. Kahn, W. Cahn, N.T. Doan, K.N. Jørgensen, T.P. Gurholt, I. Agartz, O.A. Andreassen, L.T. Westlye, I. Melle, A.O. Berg, L. Mørch‐Johnsen, A. Færden, L. Flyckt, H. Fatouros‐Bergman, E.G. Jönsson, R. Hashimoto, H. Yamamori, M. Fukunaga, A. Preda, P. De Rossi, F. Piras, N. Banaj, V. Ciullo, G. Spalletta, R.E. Gur, R.C. Gur, D.H. Wolf, T.D. Satterthwaite, L.M. Beard, I.E. Sommer, S. Koops, O. Gruber, A. Richter, B. Krämer, S. Kelly, G. Donohoe, C. McDonald, D.M. Cannon, A. Corvin, M. Gill, A. Di Giorgio, A. Bertolino, S. Lawrie, T. Nickson, H.C. Whalley, E. Neilson, V.D. Calhoun, P.M. Thompson, J.A. Turner, S. Ehrlich
Description
Summary:Objective Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
Item Description:Gesehen am 14.11.2018
Physical Description:Online Resource
ISSN:1600-0447
DOI:10.1111/acps.12718

Similar Items