Three critical hydrogen bonds determine the catalytic activity of the Diels-Alderase ribozyme
Abstract. Compared to protein enzymes, our knowledge about how RNA accelerates chemical reactions is rather limited. The crystal structures of a ribozyme that catalyzes Diels–Alder reactions suggest a rich tertiary architecture responsible for catalysis. In this study, we systematically probe the r...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 February 2012
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| In: |
Nucleic acids research
Year: 2012, Jahrgang: 40, Heft: 3, Pages: 1318-1330 |
| ISSN: | 1362-4962 |
| DOI: | 10.1093/nar/gkr812 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1093/nar/gkr812 Verlag, Volltext: https://academic.oup.com/nar/article/40/3/1318/1137573 |
| Verfasserangaben: | Stefanie Kraut, Dirk Bebenroth, Alexander Nierth, Andrei Y. Kobitski, G. Ulrich Nienhaus and Andres Jäschke |
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