Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology
Background and aims Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). Methods Gal-3BP plasma levels wer...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2016
|
| In: |
Atherosclerosis
Year: 2016, Volume: 251, Pages: 94-100 |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2016.06.002 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.atherosclerosis.2016.06.002 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0021915016302428 
|
| Author Notes: | Christian A. Gleissner, Christian Erbel, Fabian Linden, Gabriele Domschke, Mohammadreza Akhavanpoor, Andreas O. Doesch, Sebastian J. Buss, Evangelos Giannitsis, Hugo A. Katus, Grigorios Korosoglou |
| Summary: | Background and aims Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). Methods Gal-3BP plasma levels were measured by ELISA in 233 patients (63 ± 10 years, 50.2% male) undergoing computed coronary angiography tomography (CCTA). Results In 149 patients, CCTA confirmed CAD (stenosis grade >20%). Mean Gal-3BP plasma levels were 5.9 ± 2.7 μg/mL and did not differ between patients with or without CAD. Over a follow-up time of up to 4.4 years (median 2.5 years), there were 17 cases of revascularization, five cases of myocardial infarction, and five deaths (four non-cardiac, one fatal myocardial infarction). Kaplan-Meier analysis revealed that high Gal-3BP levels were significantly associated with long-term mortality (p < 0.001). Cox proportional hazards regression analysis showed that this association was independent of cardiovascular risk factors (HR 1.238, 95%-CI 1.012-1.514, p = 0.038). After adjustment for troponin T and C-reactive protein (hs-CRP) levels, significance was lost (p = 0.123). Further analysis revealed that Gal-3BP levels were significantly related to body mass index and hs-CRP levels indicating an association with metabolic and inflammatory distress. There was no correlation between Gal-3BP and calcium score, plaque volume, or vascular remodeling. Conclusions While high Gal-3BP plasma levels are associated with long-term mortality, we could not confirm it as a marker of cardiac mortality or unstable plaque morphology. |
|---|---|
| Item Description: | Gesehen am 20.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2016.06.002 |