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Cerebral amyloid angiopathy: an underdiagnosed entity in younger adults with lobar intracerebral hemorrhage?

Cerebral amyloid angiopathy (CAA) is a progressive microvascular amyloidosis affecting the small- and medium-sized arterioles and the capillaries of brain parenchyma and leptomeninges, and is recognized as a cause of lobar intracerebral hemorrhage (ICH). We report two patients who experienced recurr...

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Bibliographic Details
Main Authors: Purrucker, Jan (Author) , Hund, Ernst (Author) , Ringleb, Peter A. (Author) , Rohde, Stefan (Author) , Schönland, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Amyloid
Year: 2013, Volume: 20, Issue: 1, Pages: 45-47
ISSN:1744-2818
DOI:10.3109/13506129.2012.746937
Online Access:Verlag, Volltext: http://dx.doi.org/10.3109/13506129.2012.746937
Verlag, Volltext: https://doi.org/10.3109/13506129.2012.746937
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Author Notes:Jan C. Purrucker, Ernst Hund, Peter A. Ringleb, Christian Hartmann, Stefan Rohde, Stefan Schönland & Thorsten Steiner
Description
Summary:Cerebral amyloid angiopathy (CAA) is a progressive microvascular amyloidosis affecting the small- and medium-sized arterioles and the capillaries of brain parenchyma and leptomeninges, and is recognized as a cause of lobar intracerebral hemorrhage (ICH). We report two patients who experienced recurrent ICH due to CAA at an age of 37 (A) and 42 (B) years, respectively. The classic and modified Boston criteria for the diagnosis of CAA include an age limit of 55 years if no biopsy or postmortem examination is performed; CAA is typically not considered in the differential diagnosis of lobar ICH in younger patients. We assume that sporadic CAA is an underdiagnosed entity in younger adults with lobar ICH.Abbreviations: Aβ, amyloid β protein; AβPP: amyloid precursor protein; CAA: cerebral amyloid angiopathy; CSF: cerebrospinal fluid; ICH: intracerebral hemorrhage; MRI: magnetic resonance image; SNP: single-nucleotide-polymorphism; SWI: susceptibility weighted MR imaging; TBI: traumatic brain injury; vwD: von Willebrand disease; vWF: von Willebrand factor.
Item Description:Published online: 12 Dec 2012
Gesehen am 20.11.2018
Physical Description:Online Resource
ISSN:1744-2818
DOI:10.3109/13506129.2012.746937

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