A fast and simple method for detecting and quantifying donor-derived cell-free DNA in sera of solid organ transplant recipients as a biomarker for graft function
Background: Timely detection of graft rejection is an important issue in the follow-up care after solid organ transplantation. Until now, biopsy has been considered the “gold standard” in the diagnosis of graft rejection. However, non-invasive tests such as monitoring the levels of cell-free DNA (cf...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Clinical chemistry and laboratory medicine
Year: 2016, Volume: 54, Issue: 7, Pages: 1147-1155 |
| ISSN: | 1437-4331 |
| DOI: | 10.1515/cclm-2015-0622 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1515/cclm-2015-0622 Verlag, Volltext: https://www.degruyterbrill.com/view/j/cclm.2016.54.issue-7/cclm-2015-0622/cclm-2015-0622.xml 
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| Author Notes: | Martina Adamek, Gerhard Opelz, Katrin Klein, Christian Morath, Thuong Hien Tran |
| Summary: | Background: Timely detection of graft rejection is an important issue in the follow-up care after solid organ transplantation. Until now, biopsy has been considered the “gold standard” in the diagnosis of graft rejection. However, non-invasive tests such as monitoring the levels of cell-free DNA (cfDNA) as a sensitive biomarker for graft integrity have attracted increasing interest. The rationale of this approach is that a rejected organ will lead to a significant release of donor-derived cfDNA, which can be detected in the serum of the transplant recipient. |
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| Item Description: | Gesehen am 20.11.2018 Online erschienen: 17.11.2015 |
| Physical Description: | Online Resource |
| ISSN: | 1437-4331 |
| DOI: | 10.1515/cclm-2015-0622 |