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IL-13 Signaling in liver fibrogenesis

Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directl...

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Bibliographic Details
Main Authors: Liu, Yan (Author) , Munker, Stefan (Author) , Müllenbach, Roman (Author) , Weng, Honglei (Author)
Format: Article (Journal)
Language:English
Published: 11 May 2012
In: Frontiers in immunology
Year: 2012, Volume: 3, Pages: 1-7
ISSN:1664-3224
DOI:10.3389/fimmu.2012.00116
Online Access:Verlag, Volltext: http://dx.doi.org/10.3389/fimmu.2012.00116
Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2012.00116/full
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Author Notes:Yan Liu, Stefan Munker, Roman Müllenbach and Honglei Weng
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Summary:Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis associated genes, e.g. collagens or connective tissue growth factor, by hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis start to be uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis.
Item Description:Gesehen am 21.11.2018
Physical Description:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2012.00116

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