IL-13 Signaling in liver fibrogenesis
Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directl...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 May 2012
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| In: |
Frontiers in immunology
Year: 2012, Jahrgang: 3, Pages: 1-7 |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2012.00116 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.3389/fimmu.2012.00116 Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2012.00116/full 
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| Verfasserangaben: | Yan Liu, Stefan Munker, Roman Müllenbach and Honglei Weng |
| Zusammenfassung: | Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis associated genes, e.g. collagens or connective tissue growth factor, by hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis start to be uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis. |
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| Beschreibung: | Gesehen am 21.11.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2012.00116 |