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Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555)

Currently, it remains unclear, if patients with colon cancer and synchronous unresectable metastases who present without severe symptoms should undergo resection of the primary tumour prior to systemic chemotherapy. Resection of the primary tumour may be associated with significant morbidity and del...

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Main Authors: Rahbari, Nuh Nabi (Author) , Müller-Christmann, Christine (Author) , Bork, Ulrich (Author) , Stange, Annika (Author) , Jäger, Dirk (Author) , Luntz, Steffen P. (Author) , Englert, Stefan (Author) , Rossion, Inga (Author) , Koch, Moritz (Author) , Büchler, Markus W. (Author) , Kieser, Meinhard (Author) , Weitz, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 5 April 2012
In: BMC cancer
Year: 2012, Volume: 12
ISSN:1471-2407
DOI:10.1186/1471-2407-12-142
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2407-12-142
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1471-2407-12-142
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Author Notes:Nuh N. Rahbari, Florian Lordick, Christine Fink, Ulrich Bork, Annika Stange, Dirk Jäger, Steffen P. Luntz, Stefan Englert, Inga Rossion, Moritz Koch, Markus W. Büchler, Meinhard Kieser, Jürgen Weitz, for on behalf of the SYNCHRONOUS trial group
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Summary:Currently, it remains unclear, if patients with colon cancer and synchronous unresectable metastases who present without severe symptoms should undergo resection of the primary tumour prior to systemic chemotherapy. Resection of the primary tumour may be associated with significant morbidity and delays the beginning of chemotherapy. However, it may prevent local symptoms and may, moreover, prolong survival as has been demonstrated in patients with metastatic renal cell carcinoma. It is the aim of the present randomised controlled trial to evaluate the efficacy of primary tumour resection prior to systemic chemotherapy to prolong survival in patients with newly diagnosed colon cancer who are not amenable to curative therapy.
Item Description:We would like to thank the following centres for their commitment for SYNCHRONOUS trial.: Klinikum Ansbach, Meyer, Prof. Dr. T
Gesehen am 22.11.2018
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-12-142

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