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MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tis...

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Bibliographic Details
Main Authors: Wernicke, Caroline (Author) , Bandapalli, Obul Reddy (Author)
Format: Article (Journal)
Language:English
Published: September 2012
In: Leukemia research
Year: 2012, Volume: 36, Issue: 9, Pages: 1185-1192
ISSN:1873-5835
DOI:10.1016/j.leukres.2012.05.009
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.leukres.2012.05.009
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0145212612002342
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Author Notes:Caroline M. Wernicke, Günther H.S. Richter, Beate C. Beinvogl, Stephanie Plehm, Anna M. Schlitter, Obul R. Bandapalli, Olivia Prazeres da Costa, Uwe E. Hattenhorst, Ines Volkmer, Martin S. Staege, Irene Esposito, Stefan Burdach, Thomas G.P. Grunewald
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Summary:Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tissues. Using microarray-profiling, gene-set enrichment analysis, RNA interference and functional assays we show that MondoA overexpression increases glucose catabolism and maintains a more immature phenotype, which is associated with enhanced survival and clonogenicity of leukemia cells. These data point to an important contribution of MondoA to leukemia aggressiveness and make MondoA a potential candidate for targeted treatment of ALL.
Item Description:Gesehen am 26.11.2018
Physical Description:Online Resource
ISSN:1873-5835
DOI:10.1016/j.leukres.2012.05.009

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