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MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tis...

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Hauptverfasser: Wernicke, Caroline (VerfasserIn) , Bandapalli, Obul Reddy (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 2012
In: Leukemia research
Year: 2012, Jahrgang: 36, Heft: 9, Pages: 1185-1192
ISSN:1873-5835
DOI:10.1016/j.leukres.2012.05.009
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.leukres.2012.05.009
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0145212612002342
Volltext
Verfasserangaben:Caroline M. Wernicke, Günther H.S. Richter, Beate C. Beinvogl, Stephanie Plehm, Anna M. Schlitter, Obul R. Bandapalli, Olivia Prazeres da Costa, Uwe E. Hattenhorst, Ines Volkmer, Martin S. Staege, Irene Esposito, Stefan Burdach, Thomas G.P. Grunewald
Beschreibung
Zusammenfassung:Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tissues. Using microarray-profiling, gene-set enrichment analysis, RNA interference and functional assays we show that MondoA overexpression increases glucose catabolism and maintains a more immature phenotype, which is associated with enhanced survival and clonogenicity of leukemia cells. These data point to an important contribution of MondoA to leukemia aggressiveness and make MondoA a potential candidate for targeted treatment of ALL.
Beschreibung:Gesehen am 26.11.2018
Beschreibung:Online Resource
ISSN:1873-5835
DOI:10.1016/j.leukres.2012.05.009

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