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Von Willebrand factor and alkaline phosphatase predict re-transplantation-free survival after the first liver transplantation

BackgroundAfter liver transplantation (LT), there are liver-related, infectious and cardiovascular complications that contribute to reduced graft survival. These conditions are associated with an increase in the Von Willebrand factor antigen (VWF-Ag), which was previously correlated with survival in...

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Main Authors: Wannhoff, Andreas (Author) , Rauber, Conrad (Author) , Friedrich, Kilian (Author) , Rupp, Christian (Author) , Stremmel, Wolfgang (Author) , Weiss, Karl Heinz (Author) , Schemmer, Peter (Author) , Gotthardt, Daniel (Author)
Format: Article (Journal)
Language:English
Published: February 2017
In: United european gastroenterology journal
Year: 2017, Volume: 5, Issue: 1, Pages: 86-93
ISSN:2050-6414
DOI:10.1177/2050640616650060
Online Access:Verlag, Volltext: http://dx.doi.org/10.1177/2050640616650060
Verlag, Volltext: https://doi.org/10.1177/2050640616650060
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Author Notes:Andreas Wannhoff, Conrad Rauber, Kilian Friedrich, Christian Rupp, Wolfgang Stremmel, Karl Heinz Weiss, Peter Schemmer, Daniel N Gotthardt
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Summary:BackgroundAfter liver transplantation (LT), there are liver-related, infectious and cardiovascular complications that contribute to reduced graft survival. These conditions are associated with an increase in the Von Willebrand factor antigen (VWF-Ag), which was previously correlated with survival in cirrhotic patients.ObjectiveEvaluate VWF-Ag as a predictive marker of re-transplantation-free survival in patients after LT.MethodsWe measured VWF-Ag in patients after first LT and then followed them prospectively with regard to the primary endpoint, namely re-transplantation-free survival.ResultsThere were 6 out of 80 patients who died or received re-LT during follow-up. In these patients, the median VWF-Ag was 510.6%, which was significantly higher (p?=?0.001) than in the patients who were alive at the end of follow-up (with a median VWF-Ag?=?186.8%). At a cut-off of 286.8%, VWF-Ag was significantly correlated with re-transplantation-free survival (p?
Item Description:First published May 10, 2016
Gesehen am 27.11.2018
Physical Description:Online Resource
ISSN:2050-6414
DOI:10.1177/2050640616650060

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