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Early administration of gabapentinoids improves motor recovery after human spinal cord injury

Summary - The anticonvulsant pregabalin promotes neural regeneration in a mouse model of spinal cord injury (SCI). We have also previously observed that anticonvulsants improve motor outcomes following human SCI. The present study examined the optimal timing and type of anticonvulsants administered...

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Bibliographic Details
Main Authors: Warner, Freda M. (Author) , Weidner, Norbert (Author) , Schuld, Christian (Author)
Format: Article (Journal)
Language:English
Published: February 14, 2017
In: Cell reports
Year: 2017, Volume: 18, Issue: 7, Pages: 1614-1618
ISSN:2211-1247
DOI:10.1016/j.celrep.2017.01.048
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.celrep.2017.01.048
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124717301031
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Author Notes:Freda M. Warner, Jacquelyn J. Cragg, Catherine R. Jutzeler, Frank Röhrich, Norbert Weidner, Marion Saur, Doris D. Maier, Christian Schuld, Armin Curt, John K. Kramer
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Summary:Summary - The anticonvulsant pregabalin promotes neural regeneration in a mouse model of spinal cord injury (SCI). We have also previously observed that anticonvulsants improve motor outcomes following human SCI. The present study examined the optimal timing and type of anticonvulsants administered in a large, prospective, multi-center, cohort study in acute SCI. Mixed-effects regression techniques were used to model total motor scores at 1, 3, 6, and 12 months post injury. We found that early (not late) administration of anticonvulsants significantly improved motor recovery (6.25 points over 1 year). The beneficial effect of anticonvulsants remained significant after adjustment for differences in 1-month motor scores and injury characteristics. A review of a subset of patients revealed that gabapentinoids were the most frequently administrated anticonvulsant. Together with preclinical findings, intervention with anticonvulsants represents a potential pharmacological strategy to improve motor function after SCI.
Item Description:Gesehen am 28.11.2018
Physical Description:Online Resource
ISSN:2211-1247
DOI:10.1016/j.celrep.2017.01.048

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