Norepinephrine transporter blocker atomoxetine increases salivary alpha amylase
It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. We administered 40mg of atomoxetine, a selective NE transporter blocker that increases central NE levels, to 24 healthy a...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 January 2017
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| In: |
Psychoneuroendocrinology
Year: 2017, Volume: 78, Pages: 233-236 |
| ISSN: | 1873-3360 |
| DOI: | 10.1016/j.psyneuen.2017.01.029 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.psyneuen.2017.01.029 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0306453016305832 
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| Author Notes: | Christopher M. Warren, Ruud L. van den Brink, Sander Nieuwenhuis, Jos A. Bosch |
| Summary: | It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. We administered 40mg of atomoxetine, a selective NE transporter blocker that increases central NE levels, to 24 healthy adult participants in a double-blind, placebo-controlled cross-over design. Atomoxetine administration significantly increased SAA secretion and concentrations at 75-180min after treatment (more than doubling baseline levels). Consistent with evidence that elevation in central NE is a co-determinant of hypothalamic-pituitary-adrenal axis activity, salivary cortisol also approximately doubled at the same time points. Moreover, changes in salivary cortisol positively correlated with SAA (0.44<rho<0.56), bolstering the position that the origin of the changes in SAA reflect central NE. This work points toward the potential value of SAA as an inexpensive and non-invasive procedure to obtain information about activation of the central NE system. |
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| Item Description: | Gesehen am 28.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3360 |
| DOI: | 10.1016/j.psyneuen.2017.01.029 |