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On the biological properties of alkynyl phosphine gold(I) complexes

Golden times for metal-based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influe...

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Bibliographic Details
Main Authors: Meyer, Andreas (Author) , Alborzinia, Hamed (Author) , Can, Suzan (Author) , Wölfl, Stefan (Author)
Format: Article (Journal)
Language:English
Published: August 27, 2012
In: Angewandte Chemie. International edition
Year: 2012, Volume: 51, Issue: 35, Pages: 8895-8899
ISSN:1521-3773
DOI:10.1002/anie.201202939
Online Access:Verlag, Volltext: http://dx.doi.org/10.1002/anie.201202939
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201202939
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Author Notes:Andreas Meyer, Christoph P. Bagowski, Malte Kokoschka, Maria Stefanopoulou, Hamed Alborzinia, Suzan Can, Danielle H. Vlecken, William S. Sheldrick, Stefan Wölfl and Ingo Ott
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Summary:Golden times for metal-based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influence tumor cell metabolism, mitochondrial respiration, and angiogenesis in zebrafish embryos.
Item Description:Gesehen am 28.11.2018
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201202939

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