On the biological properties of alkynyl phosphine gold(I) complexes
Golden times for metal-based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influe...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 27, 2012
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| In: |
Angewandte Chemie. International edition
Year: 2012, Jahrgang: 51, Heft: 35, Pages: 8895-8899 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201202939 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/anie.201202939 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201202939 
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| Verfasserangaben: | Andreas Meyer, Christoph P. Bagowski, Malte Kokoschka, Maria Stefanopoulou, Hamed Alborzinia, Suzan Can, Danielle H. Vlecken, William S. Sheldrick, Stefan Wölfl and Ingo Ott |
| Zusammenfassung: | Golden times for metal-based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influence tumor cell metabolism, mitochondrial respiration, and angiogenesis in zebrafish embryos. |
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| Beschreibung: | Gesehen am 28.11.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201202939 |