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Immune defense against S. Epidermidis biofilms: components of the extracellular polymeric substance activate distinct bactericidal mechanisms of phagocytic cells

Bacteria, organized in biofilms, are a common cause of relapsing or persistent infections and the ultimate cause of implant-associated osteomyelitis. Bacterial biofilms initiate a prominent local inflammatory response with infiltration of polymorphonuclear neutrophils (PMN), the main protagonists of...

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Bibliographic Details
Main Authors: Meyle, Eva (Author) , Brenner-Weiß, Gerald (Author) , Obst, Ursula (Author) , Prior, Birgit (Author) , Hänsch, Gertrud Maria (Author)
Format: Article (Journal)
Language:English
Published: December 10, 2012
In: The international journal of artificial organs
Year: 2012, Volume: 35, Issue: 10, Pages: 700-712
ISSN:1724-6040
DOI:10.5301/ijao.5000151
Online Access:Verlag, Volltext: http://dx.doi.org/10.5301/ijao.5000151
Verlag, Volltext: https://doi.org/10.5301/ijao.5000151
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Author Notes:Eva Meyle, Gerald Brenner-Weiss, Ursula Obst, Birgit Prior, G. Maria Hänsch
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Summary:Bacteria, organized in biofilms, are a common cause of relapsing or persistent infections and the ultimate cause of implant-associated osteomyelitis. Bacterial biofilms initiate a prominent local inflammatory response with infiltration of polymorphonuclear neutrophils (PMN), the main protagonists of the local innate host defense against bacteria. In our previous work we found that PMN recognize and adhere to biofilms, and that phagocytosis and degranulation of bactericidal substances, such as lactoferrin, were initiated. In contrast to the situation with planktonic bacteria, opsonization of biofilms with immunoglobulin and complement was not required for PMN activation, suggesting that biofilms contain signaling components for PMN. In the present study we identified in the bacteria-free extracellular substance of Staphylococcus epidermidis biofilms protein fractions that activated PMN in vitro.
Item Description:Gesehen am 29.11.2018
Physical Description:Online Resource
ISSN:1724-6040
DOI:10.5301/ijao.5000151

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