Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes

Background: Glutathione-dependent catalysis is a metabolic adaptation to chemical challenges encountered by all life forms. In the course of evolution, nature optimized numerous mechanisms to use glutathione as the most versatile nucleophile for the conversion of a plethora of sulfur-, oxygen- or ca...

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Bibliographic Details
Main Author: Deponte, Marcel (Author)
Format: Article (Journal)
Language:English
Published: May 2013
In: Biochimica et biophysica acta
Year: 2013, Volume: 1830, Issue: 5, Pages: 3217-3266
ISSN:1878-2434
DOI:10.1016/j.bbagen.2012.09.018
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.bbagen.2012.09.018
Verlag, Volltext: https://linkinghub.elsevier.com/retrieve/pii/S0304416512002735
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Author Notes:Marcel Deponte
Description
Summary:Background: Glutathione-dependent catalysis is a metabolic adaptation to chemical challenges encountered by all life forms. In the course of evolution, nature optimized numerous mechanisms to use glutathione as the most versatile nucleophile for the conversion of a plethora of sulfur-, oxygen- or carbon-containing electrophilic substances.
Item Description:Published online: 1 October 2012
Gesehen am 29.11.2018
Physical Description:Online Resource
ISSN:1878-2434
DOI:10.1016/j.bbagen.2012.09.018