Towards a compendium of essential genes: from model organisms to synthetic lethality in cancer cells
Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic identification of essential gene sets not only allows insights into the fundamental building blocks of life, but may also provide novel therapeutic targets in oncology. The discovery of essen...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Critical reviews in biochemistry and molecular biology
Year: 2016, Volume: 51, Issue: 2, Pages: 74-85 |
| ISSN: | 1549-7798 |
| DOI: | 10.3109/10409238.2015.1117053 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.3109/10409238.2015.1117053 Verlag, Volltext: https://doi.org/10.3109/10409238.2015.1117053 
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| Author Notes: | Tianzuo Zhan and Michael Boutros |
| Summary: | Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic identification of essential gene sets not only allows insights into the fundamental building blocks of life, but may also provide novel therapeutic targets in oncology. The discovery of essential genes has been tightly linked to the development and deployment of various screening technologies. Here, we describe how gene essentiality was addressed in different eukaryotic model organisms, covering a range of organisms from yeast to mouse. We describe how increasing knowledge of evolutionarily divergent genomes facilitate identification of gene essentiality across species. Finally, the impact of gene essentiality and synthetic lethality on cancer research and the clinical translation of screening results are highlighted. |
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| Item Description: | Published online: 01 Dec 2015 Gesehen am 06.12.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1549-7798 |
| DOI: | 10.3109/10409238.2015.1117053 |