AC5 surgical hemostat as an effective hemostatic agent in an anticoagulated rat liver punch biopsy model
Intra-operative and postoperative bleeding is a major concern in surgical procedures for patients taking anticoagulant medications, or where anticoagulants are used to prevent potential life-threatening embolic complications. Heparin is the anticoagulant used most frequently and has an immediate eff...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2015
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| In: |
Nanomedicine. Nanotechnology, biology and medicine
Year: 2015, Volume: 11, Issue: 8, Pages: 2025-2031 |
| ISSN: | 1549-9642 |
| DOI: | 10.1016/j.nano.2015.01.001 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.nano.2015.01.001 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1549963415000118 
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| Author Notes: | Domokos Csukas, Rudolf Urbanics, Annie Moritz, Rutledge Ellis-Behnke |
| Summary: | Intra-operative and postoperative bleeding is a major concern in surgical procedures for patients taking anticoagulant medications, or where anticoagulants are used to prevent potential life-threatening embolic complications. Heparin is the anticoagulant used most frequently and has an immediate effect on blood clotting, lasting 4 to 6h. Although synthetic self-assembling peptides have been shown to achieve rapid hemostasis in small animals, none have adequately addressed the potential for hemostasis in the presence of anticoagulant therapy in-vivo. Our goal was to investigate the hemostatic activity of a known synthetic self-assembling peptide in animals treated and untreated with heparin anticoagulation therapy. Using a rat liver puncture model, animals were treated with known synthetic peptide AC5 Surgical Hemostatic Device™, or saline controls. Time-to-hemostasis and coagulation times were recorded in both heparinized and non-heparinized animals. Here we show that AC5™ was able to achieve rapid hemostasis equivalently in both heparinized and non-heparinized animals. From the Clinical Editor Intra-operative and postoperative bleeding is a major concern in surgical procedures for patients taking anticoagulant medications. In this work the effective hemostasis was demonstrated both in heparinized and non-heparinized animals using self-assembling peptides. |
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| Item Description: | Available online 15 January 2015 Gesehen am 06.12.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1549-9642 |
| DOI: | 10.1016/j.nano.2015.01.001 |