Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells
Quite aside from its immense importance as a human pathogen, studies in recent years have brought to light the fact that the malaria parasite Plasmodium falciparum is an interesting eukaryotic model system to study protein trafficking. Studying parasite cell biology often reveals an overrepresentatio...
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2012
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| In: |
Molecular and biochemical parasitology
Year: 2012, Volume: 186, Issue: 2, Pages: 95-116 |
| ISSN: | 1872-9428 |
| DOI: | 10.1016/j.molbiopara.2012.09.007 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.molbiopara.2012.09.007 Verlag, Volltext: https://linkinghub.elsevier.com/retrieve/pii/S016668511200240X 
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| Author Notes: | Marcel Deponte, Heinrich C. Hoppe, Marcus C.S. Lee, Alexander G. Maier, Dave Richard, Melanie Rug, Tobias Spielmann, Jude M. Przyborski |
| Summary: | Quite aside from its immense importance as a human pathogen, studies in recent years have brought to light the fact that the malaria parasite Plasmodium falciparum is an interesting eukaryotic model system to study protein trafficking. Studying parasite cell biology often reveals an overrepresentation of atypical cell biological features, possibly driven by the parasites’ need to survive in an unusual biological niche. Malaria parasites possess uncommon cellular compartments to which protein traffic must be directed, including secretory organelles such as rhoptries and micronemes, a lysosome-like compartment referred to as the digestive vacuole and a complex (four membrane-bound) plastid, the apicoplast. In addition, the parasite must provide proteins to extracellular compartments and structures including the parasitophorous vacuole, the parasitophorous vacuolar membrane, the Maurer’s clefts and both cytosol and plasma membrane of the host cell, the mature human red blood cell. Although some of these unusual destinations are possessed by other cell types, only Plasmodium parasites contain them all within one cell. |
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| Item Description: | Gesehen am 10.12.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1872-9428 |
| DOI: | 10.1016/j.molbiopara.2012.09.007 |