JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentia...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 August 2018
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| In: |
Nature Communications
Year: 2018, Volume: 9 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05726-z |
| Online Access: | Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-018-05726-z Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-018-05726-z 
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| Author Notes: | Karmveer Singh, Emanuela Camera, Linda Krug, Abhijit Basu, Rajeev Kumar Pandey, Saira Munir, Meinhard Wlaschek, Stefan Kochanek, Marina Schorpp-Kistner, Mauro Picardo, Peter Angel, Catherin Niemann, Pallab Maity & Karin Scharffetter-Kochanek |
| Summary: | Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentiation and impaired barrier function. |
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| Item Description: | Gesehen am 14.12.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05726-z |