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Preventive inhalation of hypertonic saline in infants with cystic fibrosis (PRESIS): a randomized, double-blind, controlled study

Cystic fibrosis (CF) lung disease starts in early infancy suggesting that preventive treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic resonance imaging (MRI) have emerged as promising endpoints of early CF lung disease, however, randomized controlled trials testing the...

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Main Authors: Stahl, Mirjam (Author) , Wielpütz, Mark Oliver (Author) , Gräber, Simon Y. (Author) , Sommerburg, Olaf (Author) , Hüsing, Johannes (Author) , Mall, Marcus A. (Author)
Format: Article (Journal)
Language:English
Published: May 15, 2019
In: American journal of respiratory and critical care medicine
Year: 2019, Volume: 199, Issue: 10, Pages: 1238-1248
ISSN:1535-4970
DOI:10.1164/rccm.201807-1203OC
Online Access:Resolving-System, Volltext: http://dx.doi.org/10.1164/rccm.201807-1203OC
Verlag, Volltext: https://www.atsjournals.org/doi/10.1164/rccm.201807-1203OC
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Author Notes:Mirjam Stahl, Mark O. Wielpütz, Isabell Ricklefs, Christian Dopfer, Sandra Barth, Anne Schlegtendal, Simon Y. Graeber, Olaf Sommerburg, Gesa Diekmann, Johannes Hüsing, Cordula Koerner-Rettberg, Lutz Nährlich, Anna-Maria Dittrich, Matthias V. Kopp, and Marcus A. Mall
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Summary:Cystic fibrosis (CF) lung disease starts in early infancy suggesting that preventive treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic resonance imaging (MRI) have emerged as promising endpoints of early CF lung disease, however, randomized controlled trials testing the safety and efficacy of preventive therapies in infants with CF are lacking.
Item Description:Originally published in press on November 9, 2018
Gesehen am 18.12.2018
Physical Description:Online Resource
ISSN:1535-4970
DOI:10.1164/rccm.201807-1203OC

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