The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma

Pilocytic astrocytoma (PA) is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced senescence (OIS), which may cause unpredictable growth behavior of PAs. The senescence-associated secretory phenotype (SASP) has been shown to r...

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Main Authors:	Buhl, Juliane (Author) , Selt, Florian (Author) , Hielscher, Thomas (Author) , Ecker, Jonas (Author) , Sahm, Felix (Author) , Ridinger, Johannes (Author) , Usta, Diren (Author) , Wefers, Annika K. (Author) , Remke, Marc (Author) , Pusch, Stefan (Author) , Oehme, Ina (Author) , Tilburg, Cornelis M. van (Author) , Kool, Marcel (Author) , Deimling, Andreas von (Author) , Herold-Mende, Christel (Author) , Korshunov, Andrey (Author) , Pfister, Stefan (Author) , Jones, David T. W. (Author) , Witt, Olaf (Author) , Milde, Till (Author)
Format:	Article (Journal)
Language:	English
Published:	15 March 2019
In:	Clinical cancer research Year: 2019, Volume: 25, Issue: 6, Pages: 1851-1866
ISSN:	1557-3265
DOI:	10.1158/1078-0432.CCR-18-1965
Online Access:	Resolving-System, Volltext: http://dx.doi.org/10.1158/1078-0432.CCR-18-1965 Verlag, Volltext: http://clincancerres.aacrjournals.org/content/early/2018/12/07/1078-0432.CCR-18-1965
Author Notes:	Juliane L. Buhl, Florian Selt, Thomas Hielscher, Romain Guiho, Jonas Ecker, Felix Sahm, Johannes Ridinger, Dennis Riehl, Diren Usta, Britta Ismer, Alexander C. Sommerkamp, J.P. Martinez-Babera, Annika K. Wefers, Marc Remke, Daniel Picard, Stefan Pusch, Jan Gronych, Ina Oehme, Cornelis M. van Tilburg, Marcel Kool, Daniela Kuhn, David Capper, Andreas von Deimling, Martin Schuhmann, Christel Herold-Mende, Andrey Korshunov, Tilman Brummer, Stefan M. Pfister, David T.W. Jones, Olaf Witt and Till Milde