Cover Image

Advanced radiation techniques in the treatment of esthesioneuroblastoma: a 7-year single-institution’s clinical experience

(1) Background: Esthesioneuroblastoma (ENB) is a rare tumor entity originating from the olfactory neuroepithelium. There is a scarcity of data about different treatment strategies. Intensity modulated radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) are advanced radiation techniques that might...

Full description

Saved in:
Bibliographic Details
Main Authors: Liermann, Jakob (Author) , Syed, Mustafa (Author) , Held, Thomas (Author) , Bernhardt, Denise (Author) , Plinkert, Peter K. (Author) , Jungk, Christine (Author) , Unterberg, Andreas (Author) , Rieken, Stefan (Author) , Debus, Jürgen (Author) , Herfarth, Klaus (Author) , Adeberg, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: 20 November 2018
In: Cancers
Year: 2018, Volume: 10, Issue: 11
ISSN:2072-6694
DOI:10.3390/cancers10110457
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3390/cancers10110457
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/10/11/457
Get full text
Author Notes:Jakob Liermann, Mustafa Syed, Thomas Held, Denise Bernhardt, Peter Plinkert, Christine Jungk, Andreas Unterberg, Stefan Rieken, Jürgen Debus, Klaus Herfarth and Sebastian Adeberg
Description
Summary:(1) Background: Esthesioneuroblastoma (ENB) is a rare tumor entity originating from the olfactory neuroepithelium. There is a scarcity of data about different treatment strategies. Intensity modulated radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) are advanced radiation techniques that might improve local tumor control. (2) Methods: This retrospective analysis contained 17 patients with ENB (Kadish stage ≥ C: 88%; n = 15). Four patients had already undergone previous radiotherapy (RT). The treatment consisted of either IMRT (n = 5), CIRT (n = 4) or a combination of both techniques (n = 8). Median follow-up was 29 months. (3) Results: In patients that had not been irradiated before (n = 13), calculated overall survival (OS) and progression free survival (PFS) rates after 48 months were 100% and 81% respectively (Kaplan-Meier estimates). Two of four patients that underwent reirradiation died after RT, presumably due to tumor progression. Besides common toxicities, five patients (30%) showed mostly asymptomatic radiation-induced brain changes, most likely due to a disturbance of the blood-brain barrier. (4) Conclusions: Our results demonstrate that IMRT, CIRT, a combined approach of IMRT and CIRT as well as reirradiation with CIRT seem to be feasible and effective treatment methods in ENB.
Item Description:Gesehen am 18.12.2018
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers10110457

Similar Items