Concise synthesis of the macrocyclic core of Rhizopodin by a heck macrocyclization strategy
A highly convergent synthesis of the central dimeric core of the potent antibiotic macrolide rhizopodin is reported. Notable features of the highly concise route include an effective preparation of the key C8-C22 building block based on an iridium-catalyzed Krische allylation and a chemoselective cro...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 16, 2012
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| In: |
The journal of organic chemistry
Year: 2012, Volume: 77, Issue: 23, Pages: 10782-10788 |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/jo302134y |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1021/jo302134y Verlag, Volltext: http://pubs.acs.org/doi/10.1021/jo302134y 
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| Author Notes: | Michael Dieckmann, Sven Rudolph, Sandra Dreisigacker, and Dirk Menche |
| Summary: | A highly convergent synthesis of the central dimeric core of the potent antibiotic macrolide rhizopodin is reported. Notable features of the highly concise route include an effective preparation of the key C8-C22 building block based on an iridium-catalyzed Krische allylation and a chemoselective crosscoupling approach toward the macrocycle involving a highly advantageous Heck reaction for macrocyclization. |
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| Item Description: | Gesehen am 18.12.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/jo302134y |