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The sickle cell trait affects contact dynamics and endothelial cell activation in Plasmodium falciparum-infected erythrocytes

Christine Lansche, Anil Dasanna et al. investigate the dynamic cytoadhesion behavior of erythrocytes infected with malaria parasite using quantitative flow chamber experiments and computer simulations. They find that parasitized erythrocytes have altered adhesion dynamics, mainly due to differences...

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Bibliographic Details
Main Authors: Lansche, Christine (Author) , Dasanna, Anil Kumar (Author) , Quadt, Katharina (Author) , Fröhlich, Benjamin (Author) , Missirlis, Dimitris (Author) , Buchholz, Bernd (Author) , Sanchez, Cecilia P. (Author) , Tanaka, Motomu (Author) , Schwarz, Ulrich S. (Author) , Lanzer, Michael (Author)
Format: Article (Journal)
Language:English
Published: 30 November 2018
In: Communications biology
Year: 2018, Volume: 1
ISSN:2399-3642
DOI:10.1038/s42003-018-0223-3
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/s42003-018-0223-3
Verlag, Volltext: https://www.nature.com/articles/s42003-018-0223-3
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Author Notes:Christine Lansche, Anil K. Dasanna, Katharina Quadt, Benjamin Fröhlich, Dimitris Missirlis, Marilou Tétard, Benoit Gamain, Bernd Buchholz, Cecilia P. Sanchez, Motomu Tanaka, Ulrich S. Schwarz & Michael Lanzer
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Summary:Christine Lansche, Anil Dasanna et al. investigate the dynamic cytoadhesion behavior of erythrocytes infected with malaria parasite using quantitative flow chamber experiments and computer simulations. They find that parasitized erythrocytes have altered adhesion dynamics, mainly due to differences in cell shape, knob density and membrane bending.
Item Description:Gesehen am 03.12.2020
Physical Description:Online Resource
ISSN:2399-3642
DOI:10.1038/s42003-018-0223-3

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