Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives
During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 August 2018
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| In: |
Nature Communications
Year: 2018, Volume: 9 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05927-6 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-05927-6 Verlag, Volltext: https://www.nature.com/articles/s41467-018-05927-6 
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| Author Notes: | Medhavi Vishwakarma, Jacopo Di Russo, Dimitri Probst, Ulrich S. Schwarz, Tamal Das & Joachim P. Spatz |
| Summary: | During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate. |
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| Item Description: | Gesehen am 09.01.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05927-6 |