Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis
The sequence of structural and molecular events during clathrin-mediated endocytosis is unclear. Here the authors combine correlative microscopy and simple mathematical growth laws to demonstrate that the flat patch starts to curve when around 70% of the final clathrin content is reached.
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 March 2018
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| In: |
Nature Communications
Year: 2018, Jahrgang: 9 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-03533-0 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-03533-0 Verlag, Volltext: https://www.nature.com/articles/s41467-018-03533-0 |
| Verfasserangaben: | Delia Bucher, Felix Frey, Kem A. Sochacki, Susann Kummer, Jan-Philip Bergeest, William J. Godinez, Hans-Georg Kräusslich, Karl Rohr, Justin W. Taraska, Ulrich S. Schwarz, Steeve Boulant |
| Zusammenfassung: | The sequence of structural and molecular events during clathrin-mediated endocytosis is unclear. Here the authors combine correlative microscopy and simple mathematical growth laws to demonstrate that the flat patch starts to curve when around 70% of the final clathrin content is reached. |
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| Beschreibung: | Gesehen am 14.01.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-03533-0 |