Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis

The sequence of structural and molecular events during clathrin-mediated endocytosis is unclear. Here the authors combine correlative microscopy and simple mathematical growth laws to demonstrate that the flat patch starts to curve when around 70% of the final clathrin content is reached.

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Bibliographische Detailangaben
Hauptverfasser: Bucher, Delia (VerfasserIn) , Frey, Felix (VerfasserIn) , Kummer, Susann (VerfasserIn) , Bergeest, Jan-Philip (VerfasserIn) , Godinez, William J. (VerfasserIn) , Kräusslich, Hans-Georg (VerfasserIn) , Rohr, Karl (VerfasserIn) , Schwarz, Ulrich S. (VerfasserIn) , Boulant, Steeve (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 March 2018
In: Nature Communications
Year: 2018, Jahrgang: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-03533-0
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-03533-0
Verlag, Volltext: https://www.nature.com/articles/s41467-018-03533-0
Volltext
Verfasserangaben:Delia Bucher, Felix Frey, Kem A. Sochacki, Susann Kummer, Jan-Philip Bergeest, William J. Godinez, Hans-Georg Kräusslich, Karl Rohr, Justin W. Taraska, Ulrich S. Schwarz, Steeve Boulant
Beschreibung
Zusammenfassung:The sequence of structural and molecular events during clathrin-mediated endocytosis is unclear. Here the authors combine correlative microscopy and simple mathematical growth laws to demonstrate that the flat patch starts to curve when around 70% of the final clathrin content is reached.
Beschreibung:Gesehen am 14.01.2019
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-03533-0