Technology, applications, and process challenges of dual chamber systems
Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, an...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2016
|
| In: |
Journal of pharmaceutical sciences
Year: 2016, Volume: 105, Issue: 1, Pages: 4-9 |
| ISSN: | 1520-6017 |
| DOI: | 10.1016/j.xphs.2015.11.025 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.xphs.2015.11.025 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022354915001409 
|
| Author Notes: | Tobias Werk, Imke S. Ludwig, Joerg Luemkemann, Hanns-Christian Mahler, Joerg Huwyler, Mathias Hafner |
| Summary: | Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, and product stability in a dual-chamber configuration, as well as economic considerations. This review serves to describe currently available dual-chamber systems and to discuss factors to be considered for appropriate selection and establishing fill-finish processes. |
|---|---|
| Item Description: | Gesehen am 23.01.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1520-6017 |
| DOI: | 10.1016/j.xphs.2015.11.025 |