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T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions

T cell activation is regulated by numerous mechanisms upon T cell antigen receptor (TCR) engagement, including induction of specific cytokines by transcription factors like NF-κB and NFAT. Tsopoulidis et al. now show that TCR engagement causes rapid nuclear actin polymerization to create a dynamic a...

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Bibliographic Details
Main Authors: Tsopoulidis, Nikolaos (Author) , Kaw, Sheetal (Author) , Laketa, Vibor (Author) , Kutscheidt, Stefan (Author) , Stolp-Rastätter, Bettina (Author) , Fackler, Oliver Till (Author)
Format: Article (Journal)
Language:English
Published: 4 January 2019
In: Science immunology
Year: 2019, Volume: 4, Issue: 31
ISSN:2470-9468
DOI:10.1126/sciimmunol.aav1987
Online Access:Resolving-System, Volltext: http://dx.doi.org/10.1126/sciimmunol.aav1987
Verlag, Volltext: http://immunology.sciencemag.org/content/4/31/eaav1987
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Author Notes:N. Tsopoulidis, S. Kaw, V. Laketa, S. Kutscheidt, C. Baarlink, B. Stolp, R. Grosse, O.T. Fackler
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Summary:T cell activation is regulated by numerous mechanisms upon T cell antigen receptor (TCR) engagement, including induction of specific cytokines by transcription factors like NF-κB and NFAT. Tsopoulidis et al. now show that TCR engagement causes rapid nuclear actin polymerization to create a dynamic actin filament network that is critical to CD4+ T cell effector functions.
Item Description:Im Titel erscheint das + bei der Zeichenfolge CD4+ hochgestellt
Gesehen am 25.01.2019
Physical Description:Online Resource
ISSN:2470-9468
DOI:10.1126/sciimmunol.aav1987

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