Endothelial cell-specific molecule-1/endocan: diagnostic and prognostic value in patients suffering from severe sepsis and septic shock
Purpose: This study aims to assess the diagnostic and prognostic value of endocan in patients with severe sepsis or septic shock on a medical intensive care unit (ICU). Methods: 150 patients suspected for at least severe sepsis were enrolled on a medical ICU. On days 1, 3, and 8, plasma levels of en...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2016
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| In: |
Journal of critical care
Year: 2016, Volume: 31, Issue: 1, Pages: 68-75 |
| ISSN: | 1557-8615 |
| DOI: | 10.1016/j.jcrc.2015.09.019 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jcrc.2015.09.019 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0883944115004797 
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| Author Notes: | Dominic Pauly, MS, Sonja Hamed, MS, Michael Behnes, MD, Dominic Lepiorz, MS, Siegfried Lang, PhD, Ibrahim Akin, MD, Martin Borggrefe, MD, Thomas Bertsch, MD, Ursula Hoffmann, MD |
| Summary: | Purpose: This study aims to assess the diagnostic and prognostic value of endocan in patients with severe sepsis or septic shock on a medical intensive care unit (ICU). Methods: 150 patients suspected for at least severe sepsis were enrolled on a medical ICU. On days 1, 3, and 8, plasma levels of endocan, procalcitonin (PCT), and interleukin (IL)-6 were measured. Follow-up on all-cause mortality was performed after 30 days and 6 months. Results: Endocan correlated with Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score II (SAPS II) (P < .006). Endocan was higher in patients with at least severe sepsis compared with systemic inflammatory response syndrome (SIRS) or sepsis patients (P = .0006) on days 1, 3, and 8. With a minimum sensitivity of 70%, uniform cutoff levels were set for ≥ sepsis at 1.8 ng/mL, for ≥ severe sepsis at 2.6 ng/mL, for ≥ septic shock at 2.9 ng/mL. On day 1, endocan levels of the fourth quartile were significantly associated with 30-days and 6-months mortality compared to lower levels. After adjustment in Cox regressions, endocan still revealed prognostic value. Conclusions: Endocan showed diagnostic capacity to diagnose patients with severe sepsis and septic shock and revealed prognostic information for 30-days and 6-months all-cause mortality. |
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| Item Description: | Gesehen am 04.02.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1557-8615 |
| DOI: | 10.1016/j.jcrc.2015.09.019 |