Dual-energy perfusion-CT of pancreatic adenocarcinoma
Purpose - To evaluate the feasibility of dual-energy CT (DECT)-perfusion of pancreatic carcinomas for assessing the differences in perfusion, permeability and blood volume of healthy pancreatic tissue and histopathologically confirmed solid pancreatic carcinoma. - Materials and methods - 24 patients...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
European journal of radiology
Year: 2013, Volume: 82, Issue: 2, Pages: 208-214 |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2012.09.012 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ejrad.2012.09.012 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X12004482 
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| Author Notes: | M. Klauß, W. Stiller, G. Pahn, F. Fritz, M. Kieser, J. Werner, H.U. Kauczor, L. Grenacher |
| Summary: | Purpose - To evaluate the feasibility of dual-energy CT (DECT)-perfusion of pancreatic carcinomas for assessing the differences in perfusion, permeability and blood volume of healthy pancreatic tissue and histopathologically confirmed solid pancreatic carcinoma. - Materials and methods - 24 patients with histologically proven pancreatic carcinoma were examined prospectively with a 64-slice dual source CT using a dynamic sequence of 34 dual-energy (DE) acquisitions every 1.5s (80ml of iodinated contrast material, 370mg/ml, flow rate 5ml/s). 80kVp, 140kVp, and weighted average (linearly blended M0.3) 120kVp-equivalent dual-energy perfusion image data sets were evaluated with a body-perfusion CT tool (Body-PCT, Siemens Medical Solutions, Erlangen, Germany) for estimating perfusion, permeability, and blood volume values. Color-coded parameter maps were generated. - Results - In all 24 patients dual-energy CT-perfusion was. All carcinomas could be identified in the color-coded perfusion maps. Calculated perfusion, permeability and blood volume values were significantly lower in pancreatic carcinomas compared to healthy pancreatic tissue. Weighted average 120kVp-equivalent perfusion-, permeability- and blood volume-values determined from DE image data were 0.27±0.04min−1 vs. 0.91±0.04min−1 (p<0.0001), 0.5±0.07 *0.5min−1 vs. 0.67±0.05 *0.5min−1 (p=0.06) and 0.49±0.07min−1 vs. 1.28±0.11min−1 (p<0.0001). Compared with 80 and 140kVp the standard deviations of the kVp120kVp-equivalent values were manifestly smaller. - Conclusion - Dual-energy CT-perfusion of the pancreas is feasible. The use of DECT improves the accuracy of CT-perfusion of the pancreas by fully exploiting the advantages of enhanced iodine contrast at 80kVp in combination with the noise reduction at 140kVp. Therefore using dual-energy perfusion data could improve the delineation of pancreatic carcinomas. |
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| Item Description: | Available online 11 October 2012 Gesehen am 05.02.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2012.09.012 |