Concise synthesis of acetal-protected syn 1,3-diols by a tandem hemiacetal formation/Tsuji-Trost reaction

Designed, developed, and applied: A novel domino sequence was used for the rapid assembly of acetal-protected syn 1,3-diols. The convergent synthesis of a polyol fragment of the macrolide antibiotic RK-397 demonstrates that this method is suitable for the rapid and stereoselective preparation of pol...

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Hauptverfasser: Wang, Liang (Verfasst von) , Menche, Dirk (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 August 2012
In: Angewandte Chemie. International edition
Year: 2012, Jahrgang: 51, Heft: 37, Pages: 9425-9427
ISSN:1521-3773
DOI:10.1002/anie.201203911
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1002/anie.201203911
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201203911
Volltext
Verfasserangaben:Liang Wang, Dirk Menche
Beschreibung
Zusammenfassung:Designed, developed, and applied: A novel domino sequence was used for the rapid assembly of acetal-protected syn 1,3-diols. The convergent synthesis of a polyol fragment of the macrolide antibiotic RK-397 demonstrates that this method is suitable for the rapid and stereoselective preparation of polyketide-type diol motifs.
Beschreibung:Gesehen am 18.02.2019
Beschreibung:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201203911