Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activ...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2000 Jan 18
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| In: |
British journal of cancer
Year: 2000, Volume: 82, Issue: 2, Pages: 488-491 |
| ISSN: | 1532-1827 |
| DOI: | 10.1054/bjoc.1999.0947 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1054/bjoc.1999.0947 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363299/ 
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| Author Notes: | H. Lage, H. Helmbach, M. Dietel and D. Schadendorf |
| Summary: | The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms. |
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| Item Description: | Gesehen am 22.02.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1532-1827 |
| DOI: | 10.1054/bjoc.1999.0947 |