Omega-3 fatty acids and mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study
Background and aims: There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality. We examined the associations of erythrocyte omega-3 fatty acids with mortality in patients referred for coronary angiography. Methods: Erythrocyte omega-3 fatty acid proportions...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2016
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| In: |
Atherosclerosis
Year: 2016, Volume: 252, Pages: 175-181 |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2016.06.049 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.atherosclerosis.2016.06.049 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0021915016302945 
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| Author Notes: | Marcus E. Kleber, Graciela E. Delgado, Stefan Lorkowski, Winfried März, Clemens von Schacky |
| Summary: | Background and aims: There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality. We examined the associations of erythrocyte omega-3 fatty acids with mortality in patients referred for coronary angiography. Methods: Erythrocyte omega-3 fatty acid proportions were measured at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC) using the HS-Omega-3 Index method. Associations of omega-3 fatty acid proportions with mortality were investigated using Cox proportional hazards regression. Results: During a median follow-up of 9.9 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. Proportions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were inversely associated with all-cause and cardiovascular mortality in models adjusted for conventional cardiovascular risk factors. The strongest association was observed for EPA with a hazard ratio (HR) of 0.89 (0.83-0.96) per increase of one standard deviation. Furthermore, we obtained evidence for a non-linear relation between EPA and mortality. Conclusions: EPA and DHA were associated with reduced mortality in LURIC, independent of other risk factors, with the association of EPA with mortality being non-linear. |
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| Item Description: | Gesehen am 25.02.2019 Available online 1 July 2016 |
| Physical Description: | Online Resource |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2016.06.049 |