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Omega-3 fatty acids and mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study

Background and aims: There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality. We examined the associations of erythrocyte omega-3 fatty acids with mortality in patients referred for coronary angiography. Methods: Erythrocyte omega-3 fatty acid proportions...

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Hauptverfasser: Kleber, Marcus E. (VerfasserIn) , Delgado Gonzales de Kleber, Graciela (VerfasserIn) , März, Winfried (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 2016
In: Atherosclerosis
Year: 2016, Jahrgang: 252, Pages: 175-181
ISSN:1879-1484
DOI:10.1016/j.atherosclerosis.2016.06.049
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.atherosclerosis.2016.06.049
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0021915016302945
Volltext
Verfasserangaben:Marcus E. Kleber, Graciela E. Delgado, Stefan Lorkowski, Winfried März, Clemens von Schacky
Beschreibung
Zusammenfassung:Background and aims: There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality. We examined the associations of erythrocyte omega-3 fatty acids with mortality in patients referred for coronary angiography. Methods: Erythrocyte omega-3 fatty acid proportions were measured at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC) using the HS-Omega-3 Index method. Associations of omega-3 fatty acid proportions with mortality were investigated using Cox proportional hazards regression. Results: During a median follow-up of 9.9 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. Proportions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were inversely associated with all-cause and cardiovascular mortality in models adjusted for conventional cardiovascular risk factors. The strongest association was observed for EPA with a hazard ratio (HR) of 0.89 (0.83-0.96) per increase of one standard deviation. Furthermore, we obtained evidence for a non-linear relation between EPA and mortality. Conclusions: EPA and DHA were associated with reduced mortality in LURIC, independent of other risk factors, with the association of EPA with mortality being non-linear.
Beschreibung:Gesehen am 25.02.2019
Available online 1 July 2016
Beschreibung:Online Resource
ISSN:1879-1484
DOI:10.1016/j.atherosclerosis.2016.06.049

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